Hong Kong Baptist University (HKBU) researchers have made a novel strategy that could conceivably produce pure, no reaction, higher quality medicinal drugs with a quicker drug revelation process. The technique includes recognizing target molecules in pesticides and pharmaceuticals in only five minutes through a particular nanomaterial layer.
Notwithstanding pharmaceutical industries, the development can be connected in monitoring the environment. The group driven by driven by Associate Professor Dr. Jeffery Huang Zhifeng and Postdoctoral Fellow Dr. Lin Yang from the Department of Physics, and Associate Professor Dr. Ken Leung Cham-fai and Postdoctoral Fellow Dr. Kwan Chak-shing from the Department of Chemistry at HKBU published their discoveries in the journal Advanced Functional Materials.
Organic molecules comprise medicinal drugs and pesticides. The chirality of every molecule has different impacts. Chirality implies the molecules are mirror images of one another like the right and left hands. An example would be naproxen, an anti-inflammatory drug whose one chiral picture treats arthritis pain while ther other can prompt harming of the liver.
With the high expense and extensive stretch of time in creating pure drugs, it isn’t valuable for pharmaceuticals to produce these. Along these lines, they manufacture drugs that have same measures of the chiral molecules or what is known as racemic mixture. This mix can have low cost in production yet it likewise prompts lower adequacy and furthermore some have toxic reactions to the body.
Dr Jeffery Huang emphasized that it is essential to recognize and find the right type of a chiral molecule during the drug disclosure process. “However, the specific nanomaterial designed and synthesised by the team, which is composed of silver chiral nanoparticles, can amplify the signal of the desired chiral molecules and improve detection sensitivity by more than 10-fold, making the location process faster, more accurate and less expensive,”
Dr. Huang reports that this creation opens the likelihood of these nanoparticles to be utilized in the drug generation processes. He stated, “We have developed a breakthrough nanomaterial which uses a simple, one-step fabrication method to sensitively detect the target drug molecules in just five minutes. The ability of the chiral nanoparticles to amplify the detection sensitivity is practically desired for trace detection.”
Dr. Ken Leung said that the nanomaterial created by the group will offer a new technique in the recognition of chiroptical purity of synthesised compounds that can produce drugs without reactions. He considers this as a breakthrough in the resolution of racemic drugs.