Group finds control of cell signaling utilizing a cobalt (III)- nitrosyl complex

Two professors’ joint research group has found how to synthesize new materials to convey nitric oxide, which controls the cell activation signal. The cell signaling control is required to contribute positively to the advancement of treatment for cardiovascular diseases.

DGIST announced on June 24 that Professor Jaeheung Cho and Professor Daeha Seo’s exploration groups in the Department of Emerging Materials Science built up a stable cobalt(III)- nitrosyl complex and affirmed the changes of the signal transmission way of nitric oxide inside the cells.

Nitric oxide controls cell activities by conveying different biochemical data including vasodilation, immune system control, and signal transmission. Notwithstanding, researchers haven’t had the option to explain the insights about nitric oxide conveyance to cells because of troubles in controlling and regulating its development, in spite of the fact that they have expected nitric oxide development to cells happens.

To recognize this, the research group synthesized a cobalt(III)- nitrosyl complex all alone, empowering extra research on nitric oxide by shedding light into it and moving nitric oxide to an ideal spot at an ideal time. Therefore, the research group affirmed contrasts in the delivery kinetics of nitric oxide to different ways in and outside the cells. The difference of conveyance speed seen by the research group is required to enormously affect the improvement of treatments later on. Whenever utilized well, an ideal chemical reaction can happen at an ideal time in a specific cell, empowering essential treatment. This can be applied to different zones since it is identified with the advancement of a ‘prodrug,’ which becomes effective in a specific area that requires treatment.

Professor Jaeheung Cho said “We highly look forward to developing a prodrug that effectively supplies nitric oxide to a necessary area or time. By expanding our research to animal behavior and human body. We plan to develop treatment for cardiovascular diseases related to vasodilation and enhancement of nueroplasticity.”

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