A New Nanomaterial by HKBU Helps in Early Detection and Diagnosis of Alzheimer’s Disease

Researchers from Hong Kong Baptist University (HKBU) have discovered a new nanomaterial that may enable the early detection and diagnosis of Alzheimer’s disorder.

The crew is mutually led with the aid of Professor Ricky Wong man-shing and Associate Professor Dr. Li Hung-wing from the branch of Chemistry at HKBU. the new nanomaterial may also be used to monitor the progression of the sickness and the effectiveness of potential pills. The study is posted in the journal Small, and the discovery has already been granted a US patent.

Non-toxic and touchy to detection, the brand new cloth can without difficulty pass through the blood-mind barrier*, permitting clear imaging – and detection – of the protein plaques which reason Alzheimer’s disease. The nanomaterial also suggests a mighty neuroprotective impact on the toxic protein.

The plaques within the mind, which made out of a protein referred to as amyloid-beta, are one of the hallmarks of the Alzheimer’s disease. The early detection of those plaques may want to help speed up the analysis of Alzheimer’s and enable people to acquire treatment in advance.

as soon as bound to amyloid-beta, the nanomaterial fluoresces and exhibits magnetic resonance houses, enabling it to be easily detected by magnetic resonance imaging (MRI) and close to-infrared imaging (NIRI) machines, which give superior resolution and do not require an invasive radioactive trace.

Fabricated the usage of a combination of superparamagnetic iron oxide nanoparticles and cyanine compounds, the group determined that the nanomaterial could without problems bypass thru the blood-mind barrier to, especially goal those amyloid-beta plaques.

Professor Wong said: “Alzheimer’s disease is the maximum common reason of dementia, and it may lead to the loss of intellectual and social competencies. The success prognosis of the sickness at an early stage may assist put off the disease’s development, however current scientific methods of brain imaging the use of Positron Emission Tomography (pet) scans are highly-priced, require invasive radiative tracers and feature-poor visibility.

“The truth that the brand new nanomaterial we have found is non-radioactive, non-toxic and able to penetrate the blood-brain barrier indicates its promise for use in near-infrared imaging (NIRI) and MRI scanning of the brain. As a result, its software as an evaluation agent for imaging is surprisingly essential and could cause in advance detection – and advanced tracking – of Alzhimer’s disease.”

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